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5-HTP is the immediate nutrient precursor to the neurotransmitter serotonin (5-HT) and it converts into serotonin in the brain. Your body uses tryptophan to manufacture 5-HTP, which is part of the reason for all the mythology about turkey making you sleepy from all the tryptophan. Serotonin is, of course, profoundly important for sleep and mood, as well as learning, sexual behavior, and hormone regulation among its many other roles in the human body.

One reason 5-HTP is such a good supplement for sleep is that it helps replenish the serotonin we naturally lose as we age. So, 5 HTP can help alleviate serotonin deficiencies as we age and help manufacture new serotonin as well.

Why GABA is one of the best sleep supplements

GABA (gamma butyric acid) is a naturally occurring chemical compound produced in the brain that helps to calm the excitability of neurons. GABA is an inhibitory neurotransmitter in the brain which has suppressive effects upon the excitatory neurotransmitters norepinephrine and glutamate. And it’s one the top sleep supplements.

GABA is also intimately tied to the parasympathetic nerve system, which is our “rest and digest” system – the polar opposite of our sympathetic nervous system’s fight or flight mechanisms in the body.

GABA become popular with mood disorders, like depression, which are tied to insomnia as well.

GABA helps to activate calming neurotransmitters in the brain helping us to get naturally sleepy. As an added bonus, GABA can also help relieve anxiety and relax the body and muscles as well. Users say taking GABA at night helps them feel very calm, drowsy, and ready for a good, long night of sleep.

When combined with 5-HTP GABA has proven effects of improving sleep quality and sleep duration as well. In fact, a new paper published in Life Sciences reports that a combination of GABA (γ-aminobutyric acid) and 5-HTP (5-Hydroxytryptophan) improved sleep and sleep duration more than the use of either of the two amino acids alone.

Valerian root has been found to be a highly effective sleep aid supplement for persons with insomnia and other sleep disorder.

Magnesium is involved in more than 300 metabolic reactions. It is essential for bone strength, a strong immune system, muscle contractions and a healthy nervous system, and it’s one of the best sleep supplements. Magnesium deficiency can result in neural over-excitation causing anxiety and restlessness and excess physical tension, insulin resistance, increased blood pressure, fatigue, irritability, poor cognitive function, lethargy, and sleep problems. It’s important to note that magnesium deficiency is very common in the U.S. and the many other developed countries. And there is indeed research showing that magnesium supplementation can improve sleep significantly.

Mucuna pruriens has significant antioxidant action that works in tandem with L-dopa to promote brain health. When L-dopa crosses the blood-brain barrier, it helps to increase brain levels of dopamine, an essential neurotransmitter associated with regulating mood and cognition.