THE STUDIES - 6 OF THEM!
Ok, now let's get down to those studies. Here are some highlights of the individual ingredient studies that MaxREP+ is formulated upon...
In a randomized, double-blinded, placebo-controlled study with crossover, 41 resistance -trained men performed 8 sets of flat barbell bench presses (4 sets at the beginning of a workout and 4 at the end) to fatigue, using 80% of their 1 repetition maximum. L-Citrulline Malate administered at an amount of 8 grams prior to exercise was shown to increase the number of repetitions (i.e., average increase of 19%) performed to failure over the 8 sets. (1)
Another study, also using a randomized, double-blinded, placebo-controlled study with crossover, utilized 12 resistance-trained men. Subjects were administered 8 grams of L-Citrulline Malate prior to exercise. Subjects performed 5 sets of repetitions to failure at 60% of their 1 repetition maximum for leg press, hack squat, and leg extension exercises. Compared to placebo, L-Citrulline Malate supplementation increased the number of repetitions to failure for all exercises. On average, a 9% increase in performance was found. (2)
In a study performed by the same group as the second study above, a randomized, double-blinded, placebo-controlled study with crossover was again used as the design. Subjects consisted of 14 resistance-trained men, who were administered 8 grams of L-Citrulline Malate prior to exercise. Subjects performed 3 sets of chin-ups, reverse chin-ups and pushups to failure. For the L-Citrulline Malate group, a significant increase in the number of repetitions performed to failure was noted for all three exercises. (3)
A randomized controlled trial that administered 6 grams of L-Citrulline daily to normal healthy men over a period of 6 days, with a single serving of 3 grams on the 7th day, found a statistically significant improvement in levels of markers of systemic NO production and bioactivity when compared to placebo. (4)
A single-serving study in young, healthy males, found that as little as 2 grams of L-Citrulline was sufficient to significantly elevate plasma levels of 1-arginine (5). L-arginine serves as a substrate in the nitric oxide synthase (NOS)-catalyzed biosynthesis of nitric oxide (NO).
STUDY 6 - A PUBLISHED REVIEW STUDY
This review focused primarily on the impact of dietary nitrate to aid physical performance and covered 31 studies, inclusive of over 300 participants. Quantitative analysis suggests that performance enhancing benefits are noted predominately with amounts ranging from 5 to 9 mmol of NO3 (nitrate). (6)